Regarding survival analysis and prognosis, the results showed that HNSCC patients with low expression levels of KLRK1 had a significantly lower overall survival (OS) rate than those with high expression levels (P < .001, as shown in Fig. 3), indicating that low expression of KLRK1 may be a prognostic factor for HNSCC. This evidence concerns the gene KLRK1 and head and neck squamous cell carcinoma.