Mele et al discovered that the infiltration of NK cells in HNSCC exhibits a unique phenotype characterized by lower expression levels of KLRK1.[11] A study on oral cancer revealed that the co-cultivation of NK cells and oral squamous cancer cell lines can boost the expression of KLRK1 in NK cells.[12] Li et al[13] have discovered, In an in vitro study using an HNSCC mouse model, Li et al[12] discovered that removing the inhibition of KLRK1 can improve the effectiveness of chemotherapy for head and neck squamous cell carcinoma. The gene discussed is KLRK1; the disease is head and neck squamous cell carcinoma.