A large amount of ROS causes serious damage to the cell structure and leads to oxidative stress.[45] In 1 study, STAT3 was found to be a central pathway that regulates oxidative stress, inflammation, and apoptosis.[46] These results suggest that melittin inhibits STAT3 expression and thus reduces ROS production, which may be one of the pathways for RA remission. This evidence concerns the gene STAT3 and rheumatoid arthritis.