Moreover, melittin reduces AKT activation and nuclear translocation of NF-κB.[38] The PI3K/AKT pathway is closely related to the regulation of chondrocyte metabolism, and AKT1 activation promotes B cell proliferation and differentiation; these processes can accelerate RA deterioration.[39] The nuclear factor NF-κB is among the crucial regulatory factors of proinflammatory gene expression. This evidence concerns the gene AKT1 and rheumatoid arthritis.