TNF and rheumatoid arthritis: KEGG, developed by the University of Tokyo and Kyoto University in Japan, is a database for systematic analysis of gene function.[31] In this study, by performing the KEGG analysis, the potential targets of melittin against of RA were associated with multiple signaling pathways, including TNF, IL-17, TLR, and AGE–RAGE signaling pathways, and bacterial and viral infections, which were mainly related to inflammatory diseases.