First, animal studies have suggested that oral intake of Vitamin C can lower plasma glucose, insulin, and triglyceride levels in diet-induced obese rats.[28] Second, Vitamin C may ameliorate insulin resistance induced by tumor necrosis factor-α in HepG2 cells by regulating the insulin receptor substrate /Protein Kinase B/glycogen synthase kinase 3β signaling pathway, thereby enhancing the expression of Glucose Transporter 2 protein. This evidence concerns the gene INSR and Insulin resistance.