SPP1 and cancer: In the study, in which the dataset used in the current study was obtained, DEFA5 and DEFA6 genes were downregulated, and SPP1 genes were upregulated for cancer-adenoma comparison.22 In this study, these genes were selected as genes that may be associated with cancer using the feature selection method, and DEFA5 and SPP1 were determined as the most important cancer-related genes according to their variable importance.