The central importance of LOX and LOXL2 in vascular development is clearly illustrated in the failure of the proper development of the cardiovascular system in mice with germline knockouts of these enzyme, and high perinatal lethality due to rupture of the diaphragm or aortic aneurysms.[67,118] In response to hypertension, the blood vessels undergo remodelling in order to be able to withstand the elevated mechanical load imposed upon them, failing which, aortic aneurysms arise. This evidence concerns the gene LOX and hypertensive disorder.