Oxidative modification of H3 K4me3 results in the repression of the CDH1 promoter, which represses transcription of the E-cadherin-encoding CDH1 gene.[110] Therefore, LOXL2-mediated modifications of the histone H3 protein and those of Snail act synergistically with respect to tumour progression. This evidence concerns the gene CDH1 and neoplasm.