Considering the relationship between hypoxia and LOX expression, N-nitroaryl derivatives of βAPN were synthesised by Granchi et al. and their antineoplastic activity was investigated in MDA-MB-231 breast cancer cells.[126] They exploited the bioreduction of nitro to hydroxylamino groups known for nitroarenes under reduced oxygen partial pressure (< 5-15 mbar),[73] whereby the βAPN derivatives undergo spontaneous 1,6-elimination with release of the inhibitor. The gene discussed is LOX; the disease is breast cancer.