LOX and neoplasm: Another oncologically relevant kinase activated by hydrogen peroxide is the tyrosine kinase Src, which in turn activates the focal adhesion kinase (FAK).[53b,61] Furthermore, integrins have been found to be activated by the formation of an intrachain disulfide bridge within the α-subunit, which in turn is induced by hydrogen peroxide.[84] In this way, both LOX and LOXL2 support tumour progression.[85]