LOX and hypertensive disorder: In mice with experimental hypertension induced by angiotensin II infusion, lysyl oxidases stabilise aneurysms,[119] and inhibition of lysyl oxidase using β-amino-propionitrile (βAPN) leads to a marked increase in the formation of aneurysms that are more prone to rupture, such that βAPN is used to induced experimental aortic aneurysms in mice.[120] Thus, in the context of development and hypertension induced aneurysms, lysyl oxidases are necessary for cardiovascular homeostasis.