Likewise, other proteins, such as lactate dehydrogenase A (LDHA), another isoenzyme previously used in the diagnosis of myocardial infarction and also involved in the proliferation of vascular smooth muscle cells (Kim et al., 2017) have been associated with arterial stiffness, one of the main phenotypes in HGPS pathology (Zhu et al., 2022). The gene discussed is ZMPSTE24; the disease is myocardial infarction.