Many excellent studies have reported on ways to enhance the therapeutic efficacy of Salmonella, such as by carrying shRNA against a critical gene of metastasis[10, 11, 12] or upregulating tumor genes,[13] expressing effector proteins, such as IFN‐γ,[14, 15] cytotoxic proteins,[16] tumor‐specific antigens,[17] covalently attaching photosensitizers,[18, 19, 20] or cytotoxic biomaterials.[21] These works were devoted to enhancing the tumor‐killing ability of oncolytic bacteria; however, they failed to address tumor colonization. The gene discussed is IFNG; the disease is neoplasm.