CD274 and neoplasm: Notably, antitumor cytokines, such as IL‐1β, IFN‐γ, and IL‐12, were upregulated ≈15‐fold, whereas neutrophil‐related tumor immune checkpoints, such as SIRPα and PDL1, and protumor markers, such as VEGF and TGFβ‐R1, were downregulated significantly.[42, 43, 44, 45]