As expected, NE(PD1nb) activated DC differentiation, thus stimulating the capacity of tumor antigen presentation, which is consistent with previous reports.[50, 56, 57] Similarly, NE(PD1nb) stimulated the M1‐like differentiation of macrophages and induced CD4+ T‐cell maturation and cytotoxic CD8+ T‐cell activation by DC tumor antigen presentation. This evidence concerns the gene CD8A and neoplasm.