KLC4 and neuromuscular disease: We demonstrated that C. elegans can be used to model disease-associated variants of human KLC4, that we can use the hKLC4 C. elegans strain generated here to test the physiological impact of other KLC4 variants, and that this strategy could be used to model neuromuscular diseases in other genes with clear orthologs in C. elegans, including LINC complexes that target kinesin light chains to the nucleus.