IL6 and obesity due to melanocortin 4 receptor deficiency: These variability factors are complex and include age, body weight, obesity, baseline status of patients, liver functions, polymorphisms of drug-metabolizing enzymes, drug interactions, and inflammatory factors such as C-reaction protein (CRP), Interleukin-6 (IL-6) and IL-1β (Koselke et al., 2012; Dolton et al., 2014; Valle-T-Figueras et al., 2021; Aiuchi et al., 2022; Li et al., 2022).