According to a preliminary investigation, fisetin inhibits the expression of matrix metalloproteinases (MMP)-2 and -9 by blocking the PI3K/protein kinase B (AKT) and c-Jun N-terminal kinase signal transduction pathways reduces PC-3 cells' capacity for metastasis on the impact of PCa.27ERK signal is involved in fisetin-mediated suppression of the invasion and migration of the human lung cancer cell line A549. This evidence concerns the gene AKT1 and lung cancer.