Caspase-3 and PARP cleavage increased expression of Bax and Bak, and inhibition of Bcl-2 and Mcl-1 all contribute to an increase in apoptosis.40In a different study, the Hsp90 inhibitors geldanamycin and gibberellin increased the cytotoxicity of human colon cancer cells induced by fisetin by triggering the mitochondrial-dependent caspase-3 cascade and hastening the protein p53's phosphorylation.41 This evidence concerns the gene CASP3 and colonic neoplasm.