According to this study, fisetin activated the caspase-8 pathway through ERK1 and ERK2 to cause apoptosis in human cervical carcinoma HeLa cells.15, 43Fisetin has been shown to block DR3-mediated NF-κB activation, induce apoptosis, and prevent invasion44in pancreatic cancer cell line AsPC-1. The gene discussed is MAPK3; the disease is cervical carcinoma.