HMOX1 and breast carcinoma: Fisetin also decreased autophagy, accelerating cell death in MCF-7 cells.79In breast cancer cells (4T1 and JC cells), fisetin increased HO-1 mRNA and protein expressions, elevated Nrf2 expression, and abolished the HO-1 expression, whereas HO-1 expression was mediated by upregulation of the transcription factor Nrf2.