MAPK3 and cervical carcinoma: Like this, treatment with fisetin in glioma gbm8401 cells can result in ongoing phosphorylation and activation of ERK1/2, blocking the metalloproteinase A disintegrin and a metalloprotease 9, which is linked to cell motility and invasion.29In addition, fisetin reduces the amount of uPA in human cervical cancer cells by blocking the nuclear factor-κB (NF-κB) signaling pathway dependent on p38 MAPK.