The inhibition of B activation is mediated by regulating kinases, including rip, TAK1, and IKK κ B α degradation and nuclear translocation of p65.45Preacetone-induced apoptosis in human bladder cancer cells is upregulated by p53 and downregulated by NF-κB activity, changing the ratio of pro- to antiapoptotic proteins. This evidence concerns the gene NFKB1 and urinary bladder cancer.