However, earlier data have shown that colorectal cancer cells treated with IFNγ can indeed take up, process, and present intact antigen in an HLA-DR–restricted manner (12) and immunologic protection of CIITA transfected is due to the generation of primed CD4+ T cells providing help for the generation of cancer antigen-specific cytotoxic T-cell effectors (7, 10). This evidence concerns the gene CD4 and cancer.