Indeed, infection with various helminths, such as S. mansoni (105), Strongyloides venezuelensis, L. sigmodontis (106), Nippostrongylus brasiliensis (107), Trichinella spiralis (108), and H. polygyrus (109, 110), have been shown to exert beneficial effects (such as improvement of glucose tolerance and insulin sensitivity) in various T2D mouse models (Table 2). This evidence concerns the gene INS and type 2 diabetes mellitus.