Globoid cell leukodystrophy or Krabbe disease is an autosomal recessive disorder caused by biallelic pathogenic variants in GALC (MIM# 245200) or PSAP (MIM# 611722) that leads to the deficiency of the enzyme galactocerebrosidase, or its activator protein saposin (22). The gene discussed is PSAP; the disease is Krabbe disease.