COL4A1 and microangiopathy and leukoencephalopathy, pontine, autosomal dominant: Pontine autosomal-dominant microangiopathy and leukoencephalopathy (PADMAL) (MIM # 618564) is a specific clinico-radiological entity that results from mutations in the 3′ UTR of COL4A1, and presents with additional clinical findings of ataxic hemiparesis, and imaging finding of prominent pontine lacunes along with the cerebral hemispheric changes (86).