CLCN2 and leukoencephalopathy with mild cerebellar ataxia and white matter edema: CLCN2-related leukoencephalopathy (MIM# 615651), also known as leukoencephalopathy with ataxia (LKPAT) is inherited in an autosomal recessive manner and is caused by a defect in water and ion homeostasis in the brain, resulting in intramyelinic edema (91).