PRF1 and neoplasm: There were linear correlations between apoptotic tumor cells and Fas ligand<sup>+</sup> TILs (r = 0.9145, p < 0.001) and perforin<sup>+</sup> TILs (r = 0.9619, p < 0.001).<h4>Conclusion</h4>T cells from HIFU-treated mice can subsequently mediate cellular antitumor immunity, which may play an important role in the HIFU-based immunomodulation.