In breast cancer, sodium/glucose cotransporter 1 (SGLT1) overexpression drives high glycolysis in tumor cells, and secreted lactate promotes polarization of M2 TAMs via activating the HIF-1α/STAT3 signaling, promoting the polarization of M2 phenotype TAMs, thus creating a vicious cycle between breast cancer cells and TAMs (89). The gene discussed is STAT3; the disease is breast cancer.