In addition, we detected soluble mIL-15 in the supernatants of both transduced Hepa1-6 tumor cells and CD3/CD28 Ab-activated H9 CAR-IL15 T cells, whereas H9 CAR-IL15 T cells produced only moderate mIL-15 upon stimulation with CLDN18.2-expressing tumor cells (Figures S1E–G). The gene discussed is CD28; the disease is neoplasm.