IL15 and neoplasm: Interestingly, we found that Panc02-claudin 18.2 pancreatic tumors had a large number of intratumoral CD31+ angiogenic cells at early time points after H9 CAR-IL15 T-cell treatment, which is consistent with a recent study showing that treatment with IL-15-modified GD2-targeting CAR-T cells increased CD31+ angiogenic cells in orthotopic glioblastoma xenografts (33), suggesting that angiogenesis and possible normalization of vasculature may be related to antitumor activity, at least in some tumor models.