FCGR3A and infection: This ITAM inhibitory signaling pathway was shown to dampen adaptive immunity to infection (89), suggesting another area of investigation related to determining whether the FcRs interactome is limited to bacteria only or extends to viruses and parasites and the consequences of these potential interaction (Figure 2); is this potential interaction protective (i.e., FcγRIIIA and S.P) or deleterious (FcγRIIIA and E. coli)?