Viral dsDNA and self-DNA, released from cells damaged by mechanical insults, UVB inflammation, and/or skin diseases such as psoriasis, can lead to increased NLRP3 activation (119, 120) In a psoriasis model, it was observed that keratinocytes stimulated by IL-17 and IL-22 upregulated Il1β, via ROS-induced NLRP3 activation (121). The gene discussed is IL1B; the disease is psoriasis.