Native CRP is predominantly synthesized in hepatocytes under transcriptional control by cytokines (IL-6 and to a lesser extent IL-1β and TNF-α), the transcription factors hepatic nuclear factor (HNF) 1α and HNF3 as part of the “reorchestration” of hepatic gene expression in response to infection or tissue injury (19), promoter methylation and a distal enhancer (29). This evidence concerns the gene CRP and infection.