Of note, interspecies mechanistic studies revealed that only the extracellular part of human MuSK protein can induce myasthenic phenotypes in both murine and rabbit NMJs, whereas murine MuSK phosphorylation is reduced when purified antibodies obtained from patients with MuSK-MG, were inoculated (49, 74, 92). The gene discussed is MUSK; the disease is myasthenia gravis.