COMT and hereditary pheochromocytoma-paraganglioma: COMT was highly expressed in 3 tumor types (KIPAN, uveal melanoma [UVM], pancreatic adenocarcinoma [PAAD]) with poor prognosis and poorly expressed in 2 tumor types (GBMLGG, pheochromocytomas, and paragangliomas [PCPG]) with poor prognosis (Figure 4B).