Also, considerable upregulation of COMT was observed in 21 cancers(GBM、GBMLGG、LGG、BRCA、LUAD、ESCA、STES、COAD、COADREAD、PRAD、STAD、HNSC、LUSC、SKCM、BLCA、THCA、READ、PAAD、ALL、LAML、CHOL) and significant downregulation in 8 cancers(KIPAN、KIRC、WT、OV、TGCT、UCS、PCPG、KICH) (Figure 3B). The gene discussed is COMT; the disease is cancer.