As shown in Figure 6B; Supplementary Table S20, DEGs in the MS_W vs. MS_O comparison mainly participated in the neuroactive ligand–receptor interaction, cocaine addiction, synaptic vesicle cycle, amphetamine addiction, calcium signaling pathway, amyotrophic lateral sclerosis (ALS), AMPK signaling pathway, Wnt signaling pathway, regulation of lipolysis in adipocytes, PPAR signaling pathway, and dopaminergic synapse. Here, PPARA is linked to cocaine dependence.