To explore the connection among transcription, lipid metabolism, and behaviors, we attempted to investigate the DEGs in the MS_W vs. MS_O comparison and uncovered some genes that may be implicated in the connection, such as Gcnt1, Plekha2, Sgpp2, and B3galt1. Their significance in the prevention and treatment of depression will need to be validated in the future by multidisciplinary research. Here, PLEKHA2 is linked to major depressive disorder.