Adult Inha KO mice have reduced Leydig cell numbers (Matzuk et al., 1992) (Figure 7B; Supplementary Figure S3C); this is supported by RNAseq data showing an approximately 5-fold reduction in Leydig cell transcripts (Insl3, Klk1b21) in Inha KO ‘normal’ tubules, TAT tubules and tumours. This evidence concerns the gene INSL3 and neoplasm.