OPTN and amyotrophic lateral sclerosis: For example, mutations of the autophagy adaptors OPTN, UBQLN2, SQSTM1 and TBK1 (a kinase for OPTN) all cause severe deficits in autophagy and link to different forms of ALS and FTD (Supplementary Table S1, D; Deng et al., 2011; Fecto et al., 2011; Burk and Pasterkamp, 2019); mutations of the ESCRTIII complex component CHMP2B cause FTDALS7/FTD3 (Skibinski et al., 2005; Clayton et al., 2015).