Although PAK1-associated oncogenesis is thought to classically depend on the interaction of PAK1 with RhoGTPases in the cytosol 13, 17, 19, 34, 35, PAK1 nuclear entry has emerged as a crucial mechanism to regulate expression of myriad downstream cancer-associated genes 12, 13, 18, 19, 36. Here, PAK1 is linked to cancer.