In addition, as a bioactive component derived from Panax notoginseng and ginseng, it was reported that ginsenoside Rk3 could exhibit a significant inhibitory effect on the proliferation and colony formation of ESCC cells by activating autophagy through the inhibition of the PI3K/Akt/mTOR signaling pathway. The gene discussed is AKT1; the disease is esophageal squamous cell carcinoma.