ANXA1 and Aortic dissection: High density lipoprotein (HDL) enhanced the level of annexin A1 (Anxa1) to inhibit endothelial cell inflammation, while Anxa1 has been shown to restrain the occurrence of acute aortic dissection by inhibiting the phenotypic transformation of vascular smooth muscle cells, suggesting that there may be drug targets for the treatment of AAD that target the inflammation response to HDL185, 186.