Plasma ATX concentration is up-regulated in elastase-induced AAA mouse model, ATX interacting with T cells by binding to integrin α4 activated the FAK/Src-RhoA signaling pathway to promote T cell migration, which in turn recruits T cells into the vessel wall and induces vascular inflammation, thereby accelerating the pathogenesis of AAA135. This evidence concerns the gene ENPP2 and triple-A syndrome.