A worthy case of back-citation is ginsenoside Ro, a novel autophagy inhibitor, that activates estrogen receptor 2 (ESR2), which consequentially activates a subunit of NADPH oxidase termed NCF1/p47PHOX (neutrophil lysyl factor 1); this cascade ultimately leads to 5-fluorouracil (5-Fu)-induced chemoresistant esophageal cancer cell death by ROS production and marked inhibition of autophagic fluxes (Zheng et al., 2016). The gene discussed is ESR2; the disease is esophageal cancer.