Furthermore, by the preapplication of N-acetyl-l-cysteine (NAC) to esophageal cancer cells, Bian et al. identified that ginsenoside Ro-induced elevated expression of autophagy-associated proteins, such as LC3B-II, was significantly reversed, precisely through the modulation of the ESR2-NCF1-ROS axis. This evidence concerns the gene ESR2 and esophageal cancer.