Unlike normal cells that die from prolonged exposure to these conditions, cancer cells strategically activate antioxidant systems and metabolic changes, including the elevated activity of antioxidants such as SOD2/MnSOD or inactivation of scavenging enzymes such as PRX1 stabilization of HIF, and activation of AMPK, to strengthen the generation of NADPH and GSH and the maintenance of redox homeostasis to thrive in harsh cancers (Jeon et al., 2012; Reczek and Chandel, 2017), thereby promoting carcinogenesis and progression (Chandel and Tuveson, 2014; Sies and Jones, 2020). Here, SOD2 is linked to cancer.