Moreover, both Rg1 and Rh2 may serve as chemosensitizers of doxorubicin, which suppresses the NF-κB signaling pathway to inhibit Dox-induced SASP (IL-8 and TNFα), thereby rescuing the viability of normal mammary epithelial cells and maintaining an inhibitory effect on cancer proliferation. The gene discussed is PPP1R3A; the disease is cancer.