Glioblastomas are diffuse, IDH wild-type astrocytic gliomas with at least one ofthe following histological or molecular features(3): microvascular proliferation; necrosis;telomerase reverse transcriptase (TERT) promoter mutation; amplification of theepidermal growth factor receptor (EGFR) gene; and gain of chromosome 7 and lossof chromosome 10. The gene discussed is TERT; the disease is glioblastoma.