Although it has a rapid onset and offset, propofol also produces respiratory depression, which occurs at multiple levels, including the respiratory central pattern generator, central chemosensitive receptors, and molecular targets, such as GABA receptors, nicotinic acetylcholine receptors (nAChRs), and TASK-1 channels [8, 9], which ultimately affects the behavioral characteristics of respiratory movement. Here, KCNK3 is linked to Respiratory insufficiency due to muscle weakness.