In this study, clinical data related to the prognosis of lung cancer were collected, and the relationship between the four SNPs in the upstream REX1 of OCT4, downstream CTBP2 and OCT4, and overall survival of lung cancer prognosis was analyzed, but there was no significant correlation between each SNP locus and the overall survival time in various genetic models. Here, POU5F1 is linked to lung carcinoma.