A previous study has revealed that 25 SNPs in the stem cell-related genes are significantly associated with the development of lung cancer the dominant genes include RAN rs14035, TP53INP1 rs7760, TP53INP1 rs896849, EPCAM rs1126497, HEY1 rs1046472, HEY2 rs3734637, OCT4 rs13409, and WNT2 rs3729629 [12]. This evidence concerns the gene POU5F1 and lung carcinoma.