PCSK5 and colorectal carcinoma: We identified 24 host genes that may be associated with the abundance of gut microbes in CRC-specific populations by SNP annotation, including the PCSK5 gene, which was consistent with the findings of Sambhawa Priya et al. [57], who identified CRC disease-specific host gene-microbiome associations using a multi-omics integration model approach different from ours, on the basis of which we found that this gene may be associated with the abundance of the genus Anaerotruncus.