Consistent with these results, significantly greater inhibition of tumor growth was found in the CAR-T.sBsAb-treated mice than in the CART-CEA.sPD-1 scFv- and CART-CEA.sTREM2 scFv-treated groups, as indicated by the tumor growth curve (Fig. 5D and Fig. S8A-E). This evidence concerns the gene CEACAM5 and neoplasm.