Studies have reported TMEM106B filament in frontal lobe in patients with familial AD, early onset AD, PD, FTLD-TDP, corticobasal degeneration, limbic-predominant neuronal inclusion body 4R tauopathy, dementia with Lewy bodies, progressive superanuclear palsy and normal aging [7–10]. This evidence concerns the gene TMEM106B and Alzheimer disease.