TARDBP and neurodegenerative disease: Interestingly, genetics studies showed that TMEM106B mutations is particularly detrimental for diseases with TDP-43 being the primary type of protein aggregates in the brain (see Sect. "Mutations in TMEM106B are risk factors for diverse neurodegenerative diseases"), suggesting that the effect of TMEM106B mutation may have certain specificity that preferentially affects TDP-43 over other types of protein aggregation.