DRD2 and major depressive disorder: The same risk allele (T) of the variant rs112646785 was previously linked to the risk of T2D and MDD comorbidity [30] and now to PCOS, confirming the closely intertwined genetic and phenotypic relationships between these complex disorders [6, 32] as well as the possible pleiotropic role of DRD2. None of the five DRD2-variants reported in our study have been linked before to the risk of PCOS and therefore are novel.