Since the TCGA classification [51] and ACRG classification [52] of GC have been reported, these two classification methods have received extensive attention.We compared the differences in inflammatory burden across subtypes and their distribution in the NII cluster system.As reported in TCGA classification [51],PD-L1 was one of the molecular characteristics of EBV,we also observed the high expression of PD-L1 in NII.clusterB-PNI. The gene discussed is CD274; the disease is gastric cancer.