CD28 and gastric cancer: Similar findings are noted in Fig. 8A. In addition,we analyzed the immunotherapy response in the tissue of GC patients after anti-PD1 treatment (Fig. 8G, CPS score obtained from pathological report), and found CD3 + /CD8 + /CD28 + T cell infiltration increased in the TME of PNI patients with a low NII score and the non-PNI patients (Fig. 8H).