Luo et al. [27] reported that IL6/STAT3 would promote VCAM1 expression in RAW264.7 in the cardiovascular system.In our results,we found that the VCAM1 expression of GC cells will also affect the phosphorylation of STAT3 in regulating PD-L1 expression.There seems to be a positive feedback regulation between VCAM1 and STAT3 in tumor cells. The gene discussed is CD274; the disease is neoplasm.