In the analysis of Western Blot(WB) of tumor tissue,VCAM1,p-STAT3 and PD-L1 in NII.clusterB-PNI were up-regulate than that in other subtypes (Fig. 3G, H).In addition,we successfully constructed VCAM1 shRNA cell models of the GC cell lines SNU-216,NCC-24,HGC-27,SNU-1 (Supplementary Figure S10A-D). Here, STAT3 is linked to gastric cancer.