Additionally, ROS are important for CD8 T cell effector maturation, as suppression of early mitochondria lowers the generation of IL-2, which is dependent on mROS, and the subsequent production of IL-2-dependent TNF, IFN-γ, perforin, and granzyme B. In conclusion, controlling ROS levels is crucial for the immune system to effectively destroy cancer cells, highlighting the potential of targeting ROS regulation as a therapeutic approach in cancer immunotherapy [147]. Here, TNF is linked to cancer.