CHEK2 and cancer: PVs were detected in 17 of these men (17.5%), 2 in BRCA1, 8 in BRCA2, 3 in ATM, 3 in CHEK2 and 1 in TP53. Thirty-two women and 8 men did not have a personal history of cancer motivating genetic testing, but typically were tested as presumed obligate carriers.