We found that 765 (16.6%) had at least one PV in any of the 13 genes that have solid evidence for a high or moderate increased risk of breast and ovarian cancer: ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, PALB2, PTEN, RAD51C, RAD51D, STK11 and TP53 [17, 18, 24]. The gene discussed is BRIP1; the disease is ovarian carcinoma.