TP53 and adenocarcinoma: Our results show that mutp53 depletion strongly downregulates ITGA5 expression in tumor cell lines from pancreatic (MIA PaCa-2, Panc-1), breast (MDA-MB231), and lung (PC9, H1975) adenocarcinomas, but not in two p53 mutant ovarian carcinoma cell lines (Fig. 1a and Supplemental Fig. S1a-e).