Depletion of mutant p53 or ENTPD5 also diminished the expression of ITGB1, the obligate binding partner of ITGA5, in the pancreatic (MIA PaCa-2), breast (MDA-MB-231), and lung adenocarcinoma (H1975), but not in the ovarian carcinoma cells (Supplemental Fig. 1g-j). Here, ITGB1 is linked to lung adenocarcinoma.