OPA1 and dementia: Our study found that the combination of DRP1 and OPA1 amplification index was significantly more predictive of MCI and dementia than either indicator alone [MCI (AUC): DRP1 + OPA1 vs. DRP1 and OPA1 = 0.9067 vs. 0.7333 and 0.8844; dementia (AUC): DRP1 + OPA1 vs. DRP1 and OPA1 = 0.9689 vs. 0.8667 and 0.9289].