Multiple logistic regression model 0 showed that DNA amplification factor of DRP1 was independently correlated with DM-related dementia(P = 0.009), and amplification factor of OPA1 was independently correlated with both diabetes-related MCI (P = 0.007) and dementia(P = 0.002), and this effect persisted after adjusting for HbA1c and LDL in Model 1. The gene discussed is OPA1; the disease is diabetes mellitus.