Purine-Rich Element-Binding Protein A (PURA) causes a neurodevelopmental disorder with neonatal respiratory insufficiency, hypotonia, and feeding difficulties (MIM#616158), and Pyrroline-5-Carboxylate Reductase 2 (PYCR2) causes hypomyelinating leukodystrophy 10 (MIM#616420). The gene discussed is PYCR2; the disease is Respiratory insufficiency.