Mutations on ATP7A, the ATPase copper transporting alpha protein, cause Menkes disease (MIM#309400), a copper metabolism disorder leading to infant-onset encephalopathy, known by the coarse, kinky or steely hair on patients.22 We collected previously reported disease-causing variants (Fig. 3a), and found that nonsense variants are a common cause of the disease. The gene discussed is ATP7A; the disease is Menkes disease.