Among markers identified on metastatic melanoma cells, protein expression did not correlate with the corresponding gene expression in almost 50% of all markers (6 out of 13—CD56, CD70, CD71, CD81, CD107a, and CD274) showing that application of CITE-seq extended antibody panels can reveal unusual surface markers that would otherwise be missed based on mere RNA profiling. This evidence concerns the gene CD81 and melanoma.