Examples of genetically anchored protein–disease connections included: TNFSF11 (RANKL) with osteoporosis and hypothyroidism, NGF (nerve growth factor) with migraine, TNFSF12 (TWEAK) with hypertension and fibroblast growth factor 5 (FGF5) with hypertension and cardiovascular diseases. The gene discussed is TNFSF12; the disease is migraine disorder.