The SCNA comprised focal losses in 8p11.22 including the metallopeptidase genes ADAM18 and ADAM32 in 22% of lFL (q = 1.4E-15) and focal gains affecting 11q24.3 harboring cancer-associated genes ETS1 and FLI1 in 22% of lFL (q = 2E-27). This evidence concerns the gene ADAM18 and cancer.