Similar results were obtained by inhibiting or knocking down FASN in mouse embryonic fibroblasts (MEFs; Extended Data Fig. 4a–c), MCF-7 human breast cancer cells (Extended Data Fig. 4d–g), WI-26 human lung fibroblasts (Extended Data Fig. 4h,i) and U2OS human osteosarcoma cells (Extended Data Fig. 4j,k), showing that this effect is not cell-type- or species-specific. The gene discussed is FASN; the disease is osteosarcoma.