Additionally, Snail can cooperate with other transcription factors, such as ZEB1, to inhibit the expression of the Crumbs cell polarity component LGL2 at the transcription level and inhibit the expression of the Pals1-related tight junction protein PATJ, which changes cell polarity, decreases or eliminates intercellular adhesion, and promotes tumour invasion and metastasis24,25. The gene discussed is SNAI1; the disease is neoplasm.