Further, in a study comparing 10 different murine models, CT26 had tenfold higher cytolytic activity (defined in this study as the log average expression of two key cytolytic effectors, granzyme A and perforin) when compared to TGCA CRC data, and was the best responder to anti-CTLA-4 therapy [19]. This evidence concerns the gene CTLA4 and colorectal carcinoma.