VdUlpB-mediated deSUMOylation of VdEno could be important in regulating VdSCP8 expression during early plant infection, while at the later infection time points, reduction in both VdUbc9 and VdUlpB resulted in reduced post-translational SUMOylation, thus no need of deSUMOylation of VdEno and more distribution in the cytoplasm, which allowed it to function as a glycolytic enzyme, and this led to derepression of VdSCP8 in the nucleus. The gene discussed is HK1; the disease is infection.