In addition, considering that ZHX2 is significantly upregulated in HCC cells treated with I-125, the circSEC11A/miR-3529-3p/ZHX2 axis was established using several bioinformatics websites to predict the interaction between circRNA, miRNA, and mRNA, which was verified using RIP, RNA pull-down, and dual-luciferase reporter assays. This evidence concerns the gene ZHX2 and hepatocellular carcinoma.