Importantly, hm5C favors mRNA translation.190 However, the biofunction of hm5C in mammalian RNA is largely unknown until Shen et al. discovered that TET2 was involved in RNA stability.191 These findings uncovered that TET2, depending on its enzymatic activity of mRNA oxidation, promoted pathogen infection-associated myelopoiesis. Here, TET2 is linked to infection.