As a member of the TET family, the main role of TET3 is implicated in demethylation in many biological processes such as zygote formation,128–131 embryogenesis,132 axon regeneration,133 and synaptic transmission.134 For example, TET3-mediated DNA demethylation is necessary for liver tissue maturation via proper hepatocyte gene expression.135 In addition, TET3 deficiency induced by mutations is associated with abnormal growth and intellectual disability,136 indicating the fundamental role of TET3 in development. Here, TET3 is linked to Intellectual disability.