TET3 and Autoimmunity: TET2 and TET3 are required for Treg cell stability and immune homeostasis,152 and improve Treg cell efficacy by increasing the stability of FOXP3.153 TET2 and TET3 acted as recruiters of HDACs to suppress CD86 and prevent autoimmunity.154 Findings also reveal the roles of TET2 and TET3 in embryonic heart development155 and in regulating proper development and maturation of invariant natural killer T cells.156 Knockdown of TET2 led to hyper-proliferation of erythroid progenitors, whereas knockdown of TET3 impaired terminal erythroid differentiation.