Considering hm5C accounting for approximately 0.02% of total m5C RNA in tumor samples, this implied the involvement of TET2 in RNA biology.189 Consistently, a study in Drosophila showed that TET protein was involved in the formation of hm5C.190 This study also mapped the distribution of hm5C and revealed hm5C located in coding sequences of many gene transcripts. This evidence concerns the gene TET2 and neoplasm.