These findings revealed distinct roles of TET2 and TET3 in the regulation of human erythropoiesis.157 Furthermore, the deletion of TET2 and TET3 led to aggressive myeloid cancer in mice.158 Mice with TET2 and TET3 double knockout in mature B cells developed B cell lymphoma, which can be delayed upon DNMT1 deletion,159 suggesting the importance of proper methylome. This evidence concerns the gene TET3 and B-cell non-Hodgkin lymphoma.