While the phosphorylation of TET2 was inhibited under hyperglycaemic conditions such as diabetes, consequently decreasing TET2 levels.223 Monoubiquitylation of TET2 at lysine 1299 mediated by VprBP facilitated TET2 association to chromatin, whereas mutation of TET2 at 1299 blocked its interaction with VprBP and decreased its association with DNA.224 Interestingly, the K1299-linked monoubiquitylation of TET2 could be removed by USP15, decreasing TET2 association to DNA.225 Additionally, phosphorylation of TET3 by CDK5 caused lower binding affinity to histone variant H2A.Z. This evidence concerns the gene TET2 and diabetes mellitus.